Matthews Lab Publications

2012| 2011|2010|2009|2008|2007 | 2006 | 2005 | 2004 | 2003 | Older

 

 

2012

MacGregor, P. and Keith R. Matthews (2012)

Identification of the regulatory elements controlling the transmission-stage specific gene expression of PAD1 in Trypanosoma brucei.

Nucleic Acids Research. In press

 

MacGregor, P.; Szoor, B.; Savill, N. and Keith R. Matthews (2012)

Trypanosome Immune evasion, chronicity and transmission: an elegant balancing act

Nature Reviews Microbiology doi:10.1038/nrmicro2779

 

Little, TJ, Allen, JE, Babayan, SA, Matthews, KR, & N. Colegrave (2012)

Harnessing evolutionary biology to combat infectious disease.

Nature Medicine, 18: 217-220.

 

2011

Walrad, Pegine; Capewell, Paul; Fenn, Katelyn and Keith R. Matthews (2011)

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei.

Nucleic Acids Research PMID: 22140102

G. Adam Mott, Raymond Wilson, Anuruddika Fernando, Ailie Robinson, Paula
MacGregor, David Kennedy, Dick Schaap, Jacqueline B. Matthews and Keith R. Matthews

Targeting cattle-borne zoonoses and cattle pathogens using a novel trypanosomatid
based delivery system.

PLoS Pathogens, 7 (10): e1002340.

 

MacGregor P, Savill NJ, Hall D, Matthews KR.

Transmission stages dominate trypanosome within-host dynamics during chronic infections.

Cell Host Microbe. 2011 Apr 21;9(4):310-8.

Matthews, K. R.

Controlling and co-ordinating development in vector-transmitted parasites

Science. Vol. 331 no. 6021 pp. 1149-1153

 

Pollit, L.C.; MacGregor, P.; Matthews, K. R. and Reece, S.

Malaria and trypanosome transmission: different parasites, same rules?
Trends in Parasitology, Feb 21. [Epub ahead of print]

Natesan SK, Black A, Matthews KR, Mottram JC, Field MC.

Trypanosoma brucei brucei: Endocytic recycling is important for mouse infectivity.
Exp Parasitol. 2011 Jan 20. [Epub ahead of print]

2010

Barnwell E, Van Deursen F, Jeacock L, Smith K, Maizels R, Acosta-Serano A and Matthews KR

Developmental regulation and extracellular release of a VSG expression site-associated gene product from Trypanosoma brucei bloodstream
forms

Journal of Cell Science , Oct 1;123(Pt 19):3401-11.

Chan K, Matthews KR and Erfeld, K.

Functional characterisation and drug target validation of a mitotic Kinesin-13 in Trypanosoma brucei

PLoS Pathogens, 19;6(8). pii: e1001050.

Szoor B, Ruberto I, Burchmore R and Matthews, K.R.

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signalling pathway

Genes and Development, 24(12):1306-16.

MacGregor, P and Matthews, K.R.

New discoveries in the transmission biology of sleeping sickness parasites: applying the basics

Journal of Molecular Medicine , 88(9):865-71. Epub 2010 Jun 5.

Barbara M. Bakker, R. Luise Krauth-Siegel, Christine Clayton, Keith Matthews,
Mark Girolami, Hans V. Westerhoff, Paul A. M. Michels, Rainer Breitling, Michael
P. Barrett

The Silicon trypanosome

Parasitology, May 6:1-9. [Epub ahead of print]

Droll D, Archer S, Fenn K, Delhi P, Matthews K, Clayton C.

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation.

FEBS Lett. 2010 Feb 11. [Epub ahead of print]

2009

Natesan SK, Peacock L, Leung KF, Matthews KR, Gibson W, Field MC.

The trypanosome Rab-related proteins RabX1 and RabX2 play no role in intracellular trafficking but may be involved in fly infectivity.

PLoS One. 2009 Sep 29;4(9):e7217.

Kabani, S.; Watefall, M. and Matthews K.R.

Cell-cycle synchronisation of bloodstream forms of Trypanosoma brucei using Vybrant DyeCycle Violet-based sorting.

Mol Biochem Parasitol. 2010 Jan;169(1):59-62.

Kabani, S,; Fenn, K.; Ross, A.; Ivens, A.; Smith, T.K.; Ghazal, P. and Matthews K. R. (2009)

Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei.

BMC Genomics. 2009 Sep 11;10:427.

 

Dean, S.; Marchetti, R.; Kirk, K. and Matthews K.R. (2009)

A surface transporter family conveys the trypanosome differentiation signal

Nature 459: 213-217

 

Walrad, P.; Paterou, A.; Acosta-Serrano, A. and Matthews, K.R. (2009)

Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements

PLoS Pathogens, Feb 5(2):e1000317.

2008

Matthews, J.B.; Johnson, D.R.; Lazari, O.; Craig, O. and Matthews, K. R. (2008)

Identification of a LIM domain-containing gene in the Cyathostominae
Veterinary Parasitology 154(1-2):82-93.

MacGregor, P and Matthews, K.R. (2008)

Modelling trypanosome chronicity: VSG dynasties and parasite density.

Trends in Parasitology. 24(1):1-4.[INVITED ARTCLE]

 

2007

Dean, S.D and Matthews, K.R. (2007)

Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites. [INVITED "PREVIEW']

'Cell'- Host and Microbe.2(5):279-28

Brenchley, R.; Tariq, H.; McElhinney, H.; Szoor, B.; Stevens, R.; Matthews, K.R. and Tabernero L. (2007)

The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains

BMC Genomics. 8(1):434

Fenn, K and Matthews, K.R. (2007)

The Cellular Biology of Trypansoma brucei development. [INVITED "REVIEW"]

Current Opinion in Microbiology. Nov 8; [Epub ahead of print].

Natesan, S.K.; Peacock, L.; Matthews,  KR.; Gibson, W. and Field, MC. (2007)

Activation of the endocytic system as a component of adaptation to the mammalian host in the African trypanosome.

Eukaryotic Cell: 6(11):2029-37.

Spoerri, I.; Chadwick, R.; Kunz-Renggli, C.; Matthews, K.R.; Roditi, I. and Burkard, G. (2007)

Role of the stage-regulated nucleoside transporter NT10 in differentiation and adenosine uptake in Trypanosoma brucei. Molecular and Biochemical Parasitology. 154(1):110-4.

Hendriks, E. and Matthews, K.R. (2007)

Post transcriptional control of gene expression in African trypanosomes. Book Chapter in “Trypanosomes — After the Genome”.Chapter 7. pp209-237. Horizon Press.

 

2006

Szöőr, B; Wilson, J., McElhinney, H.; Tabernero, L. and Matthews KR (2006)

Protein tyrosine phosphatase TbPTP1: a molecular switch controlling life cycle differentiation in Trypanosoma brucei. Journal of Cell Biology. 175(2):293-303.

Paterou A, Walrad P, Craddy P, Fenn K, Matthews K. (2006)

Identification and stage-specific association with the translational apparatus of TbZFP3, a ccch protein that promotes trypanosome life cycle development. J Biol Chem. 281(51):39002-13

Matthew Mayho, Katelyn Fenn, Paul Craddy, Susan Crosthwaite and Matthews, K. (2006)

Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements. Nucleic Acids Research. 34(18):5312-24.

 
Subramaniam, C.; Veazey, P.; Redmond, S.; Hayes-Sinclair, J. Chambers, E.; Carrington, M.; Gull, K.; Matthews, K.R*.; Horn, D.*, Field, M.* (* joint corresponding authors) (2006)

A chromosome-wide analysis of gene function by RNAi in the African trypanosome. Eukaryotic Cell. 5: 1539-1549.

Christian J. Janzen , Frederick van Deursen, Huafang Shi, George, A. M. Cross, Keith, R.  Matthews and Elisabetta Ullu. (2006)

Expression site silencing and life-cycle progression appear normal in  Argonaute1-deficient Trypanosoma brucei. Mol Biochem parasitol. 149(1):102-7.

A.E. Gruszynski, F.J. van Deursen, students of the ‘Biology of Parasitism 2003’ course, K.R. Matthews, and J.D. Bangs. (2006).

Regulation of Surface Coat Exchange by Differentiating African Trypanosomes. Mol Biochem parasitol. 147(2):211-23.

2005

Alasdair C. Ivens, et al. (2005)

The genome of the kinetoplastid parasite, Leishmania major. Science 309(5733):436-42.

Matthews, K. R.  (2005)

‘Parasites revisited’ Book Review of The Trypanosomiases. Trends in Parasitology

Hendriks, E. and Matthews, K. R. (2005)

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein. Molecular Microbiology  57: 706-716.

Johnston CE, Bradley JE, Behnke JM, Matthews KR, Else KJ.

Isolates of Trichuris muris elicit different adaptive immune responses in their murine host. Parasite Immunol. 2005 27(3):69-78.

K. R. Matthews (2005)
The developmental cell biology of Trypanosoma brucei. Journal of Cell Science 118(Pt 2):283-90.

2004

Matthews. K.R., Melville, S. and Turner, CMR. (2004)

The application of genomic technology to combat scientific disease. Editorial preface to Parasitology special supplement.  Parasitology 128: S1-S2

J.R. Ellis, M. Sarkar, E.F. Hendriks, and K. R. Matthews (2004).

A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension. Molecular Microbiology 53: 1487-1500.

M. A. Sanchez, S. Drutman, M. van Ampting, K.R.  Matthews and S.M. Landfear.

A Novel Purine Nucleoside Transporter whose Expression is Upregulated in the Short Stumpy Form of the T. brucei Life Cycle. (2004). Molecular and Biochemical parasitology  136: 265-272.

Matthews, K.R.; Ellis, J and Paterou, A. (2004).

The molecular regulation of the trypanosome life cycle. Trends in Parasitology. 20(1):40-47.

2003

E. F. Hendriks, Abdul-Razak, A. and K. R. Matthews (2003).

tbCPSF30 depletion by RNAi disrupts polycistronic RNA processing in Trypanosoma brucei. Journal of Biological Chemistry. 278(29):26870-8.

van Deursen, F.J ; Francis, S and Matthews, K.R. (2003)

A reproducible protocol for analysis of the proteome of Trypanosoma brucei. Molecular and Biochemical Parasitology  128:107-110.

Key Earlier publications

Timms, M.; van Deursen, F.J; Hendriks, E. and Matthews, K.R. (2002)

Mitochondrial development during life-cycle differentiation of the African trypanosome: evidence for a kinetoplast-dependent differentiation control point. Molecular Biology of the Cell. 13: 3747-3759.

Hendriks, E.; Robinson, D.R. , Hinkins, M and Matthews, K.R. (2001).

A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form. EMBO J. 20:6700-6711.

Tasker, M. Timms, M., Hendriks, E. and Matthews K.R. (2001).

Mitochondrial cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved leader sequence and is developmentally regulated at both RNA and protein levels. Molecular Microbiology 39:272-285.

Tasker, M.; Wilson, J., Sarkar, M., Hendriks, E. and Matthews K.R. (2000).

A novel selection scheme for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome. Molecular Biology of the Cell 11:1905-1917.

Bastin, P.; MacRae, T.; Frances, S.B.; Matthews, K.R. and Gull, K. (1999).

Flagellar Morphogenesis: protein targetting and assembly in the paraflagellar rod of trypanosomes. Molecular and Celluar Biology 19: 8191-8200.

Matthews, K.R. and Gull, K. (1997).

Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form. Journal of Cell Science. 110: 2609-2618.

Matthews, K.R.; Sherwin, T. and Gull, K (1995).

Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated. Journal of Cell Science 108: 2231-2239.

Matthews, K.R. and Gull, K. (1994).

Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms in the African trypanosome. Journal of Cell Biology. 125: 1147-1156.

Matthews K.R.; Tschudi, C. and Ullu, E. (1994).

A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. Genes and Development. 8: 491-501.

Tschudi, C.; Matthews, K.R. and Ullu, E. (1993).

Temporal order of RNA processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly-synthesised tubulin transcripts. Molecular and Cellular Biology. 13: 720-725.