I am interested in the molecular basis of adaptive evolution. By applying population-genetic approaches to host-parasite systems, I hope to understand how the selective pressure exerted by host-parasite interaction translates into adaptive change in the genome.
Most of my current work focuses on Drosophila and their viral pathogens, but I also have side interests in other pathogens and parasites of wild drosophila, and host-parasite coevolution in other insect systems, such as Anopheles mosquitoes, and nearly-insects, such as Daphnia.
|2008-present||University of Edinburgh||Wellcome Trust Research Career Development Fellow "The demography, population genetics and genome evolution of viral pathogens in an innate immunity model|
|2004-2008||University of Edinburgh||Wellcome Trust Grant to Tom Little "Pathogen-mediated selection on the immunity genes of disease carrying mosquitoes in the genus Anopheles"|
|2000-2004||University of Oxford||D.Phil. "Genetic variation and sexual system evolution in the annual mercuries" supervised by Dr. John Pannell and Dr. Stephen Harris in the department of Plant Sciences|
|1997-2000||University of Cambridge||B.A. (Hons) Natural Sciences (Part II Plant Sciences)|
Obbard DJ, Maclennan J, Kim K-W, Rambaut A, O'Grady PM, Jiggins FM, (2012) Estimating divergence dates and substitution rates in the Drosophila phylogeny. Molecular Biology and Evolution 29 (11): 3459-3473
Longdon B, Hadfield JD, Webster CL, Obbard* DJ, Jiggins* FM (2011) Host phylogeny determines viral persistence and replication in novel hosts PLoS Pathogens 7(9):e1002260
Obbard DJ, Jiggins FM, Bradshaw NJ, Little TJ (2011) Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila. Molecular Biology and Evolution 28(2): 1043-1056
Obbard DJ, Welch JJ, Kim K-W, Jiggins FM (2009) Quantifying Adaptive Evolution in the Drosophila Immune System. PLoS Genet 5(10): e1000698.
Obbard DJ, Gordon KHJ, Buck AH, Jiggins FM (2009) The evolution of RNAi as a defence against viruses and transposable elements. [Review] Philosophical Transactions of the Royal Society Series B 364 99-115.
Obbard DJ, Jiggins FM, Halligan DL, Little TJ (2006). Natural selection drives extremely rapid evolution in antiviral RNAi genes. Current Biology 16: 580-585.